Interrogating the role of m6A mRNA methylation in the aging of the β-cell and diabetes
The goal of this project is to use state-of-the art methods to characterize the m6A methylome of the aging β-cell and identify m6A-regulated pathways that underlie the accelerated β-cell aging in diabetes.
Investigating RNA modifications and the impact of healthspan interventions
The goal of this project is to examine specific RNA modifications associated with age-related metabolic disorders (e.g., diabetes and obesity) and health interventions (e.g., exercise, caloric restriction, intermittent fasting).